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Ciprofloxacin hcl for typhoid fever, and a placebo. No significant statistical differences between groups were observed in the frequency of symptoms (4 patients [0% and 11.0%] in the flu-only group vs. 23 patients [17% and 48.0%] in the placebo group; P=0.5) ( ). The main outcome measures were occurrence of the main adverse events and efficacy. The main adverse events were gastrointestinal bleeding (12%), headache (7%), and the frequency of anorexia was reduced (5%). However, in the placebo group incidence of gastrointestinal bleeding was increased in a dose-dependent fashion (P<0.05). The rate of fever was statistically significantly decreased at all doses (4.2%; 95% CI 0.9% to 6.4%; P<0.01), but the flu-only group showed statistically significant (P<0.01) reduction (5.7%; 95% CI 1.2% to 10.8%; P<0.01). The percentage of patients who had pain or muscle aches at the end of treatment was statistically significantly lower during the flu-only period (8.6%; 95% CI 0.9% to 21.5%; P<0.01) compared with placebo. The incidence of adverse events during the 12 weeks' course of vaccine study were comparable between the two groups (2.4% flu vaccine and 1.8% placebo). No severe adverse events occurred, and in the placebo group there were some instances of hypersensitivity reactions. The duration clinical trial was 10 weeks. The efficacy at end of four weeks was 84.5% in the 2.4 μg/kg/day flu-only group (95% confidence interval 83.4% to 86.8%). At the 12-week end-point, flu vaccine was effective in 88% (80.3% to 97.6%) the 2.4 μg/kg/day flu-only group, and this rate of effectiveness was further increased with increasing dose throughout the course of trial ( ). Discussion Our results show that in a population-based placebo-controlled trial, single dose of 2.4 μg/kg/day flu vaccine is effective in preventing the development of disease by circulating influenza virus. Flu shots also significantly reduce the frequency of more serious complications influenza disease. Our statistical analysis shows influenza vaccine to be a safe intervention with significant efficacy that is likely to prevent severe diseases in the population-based study. It is also possible that the efficacy of vaccine is dependent on the number of doses received. However, this analysis did not Sildenafil 20 mg dose reveal any difference in efficacy at 4 week intervals. There have been very conflicting reports regarding the effectiveness of influenza vaccine, and the reasons for such lack of evidence include: a statistical power as result of the small numbers subjects, an inability to control for the variability in clinical and viral susceptibility, a lack of randomization and delay in reporting of outcome data [7–11]. The results from placebo control trial conducted in the United States showed a lack of efficacy for this particular study among healthy persons. In a study from Italy that also evaluated a flu vaccine administered for two years, the flu shot alone prevented disease when given at least every two years [11]. However, in the case of Italian vaccine, no significant change in clinical course was observed, and the risk of complications was maintained in healthy adults. The effectiveness of placebo is expected to be greater in patients who are at higher risk of complications due to influenza, and there are many reports from around the world indicating effectiveness for patients who were hospitalized [12–16]. In contrast to the study conducted in United States, a recent placebo-controlled vaccine study involving patients at high risk in Norway showed that the efficacy of flu vaccine differed between patients who were in the high-risk subgroup and those in the low-risk subgroup [17]. We and our colleagues recently showed that the use of active control group children in our flu vaccine trials was associated with significantly lower vaccine efficacy than a study designed with active placebo control groups [18]. A few observational studies have reported an association between vaccination and a decrease in the frequency of acute respiratory syndrome (ARDS) and death due to influenza complications[19, 20]. However, the study conducted by US Centres for Disease Control and Prevention (CDC) did not find an increase in respiratory complications or mortality after influenza vaccination [21]. Cytotec misoprostol online A recent study of influenza vaccine administered to pregnant women had similar findings to the others [22]. In UK, there is one study reporting a significant decrease in incidence of influenza-related complications the first 2 weeks after vaccination versus unvaccinated individuals [23] and no differences in incidence of the following complications: bronchitis, pneumonia and otitis media when compared with placebo groups. However, in the case of 2-year study conducted in the United Kingdom, there was.
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